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http://mobile.nytimes.com/2016/07/21/business/generic-crestor-wins-approval-dealing-a-blow-to-astrazeneca.html Yay!

Tjaden Froyda @ about 1 year ago

Comments (45)

6c48fb73634fa41fe7915a7faf370ee7

incredible news! Congratulations unhealthy people

Mr. Pink @ about 1 year ago

North Royalton, OH 44133, USA

B35527b232c45def78db4f6949419182

and Chevy Chase looking mofos

Tjaden Froyda @ about 1 year ago

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In all seriousness, this will save taxpayers lots.

Tjaden Froyda @ about 1 year ago

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https://www.cms.gov/Newsroom/MediaReleaseDatabase/Fact-sheets/2015-Fact-sheets-items/2015-12-21.html

Tjaden Froyda @ about 1 year ago

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Those guys will try anything. It's worth paying the lawyers to be creative...lots of money each day they can hang onto exclusivity.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

7feb020fb3d3aa6cf2752031cf61da89

they should just give away the drug & research involved. . that way everyone could benefit .

H2O @ about 1 year ago

Spotsylvania Courthouse, VA 22553, USA

B35527b232c45def78db4f6949419182

Except that's not what happened here. AZ tried to evergreen Crestor by saying since it was recently approved to treat a rare cholesterol disorder for kids, therefore they should keep the patent.

Tjaden Froyda @ about 1 year ago

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Really h2o?

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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They had their period of exclusivity under the law. They made plenty of money, and even though the taxpayers subsidized the work they kept all the profit. They had a good run. Now it's time for the other half of the patent contract to kick in.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

that contract says, we'll give you a legal monopoly for your invention. But at the end of the term, your patent document will be public property...everything it teaches, like how to make the drug etc.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

6c48fb73634fa41fe7915a7faf370ee7

shame dinga ling shame dinga ling shame....

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

C767f03aeb282b9660d8157840047228

It's time for the American people to have that for which they paid very, very dearly. I'm sure you'll find some grumpy reason this is unsatisfactory. Just be careful, because this is an area where I know a universe of stuff you do not.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

6c48fb73634fa41fe7915a7faf370ee7

you poor thing Doc we see your pain

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

7feb020fb3d3aa6cf2752031cf61da89

really, .

H2O @ about 1 year ago

Spotsylvania Courthouse, VA 22553, USA

7feb020fb3d3aa6cf2752031cf61da89

now as far as your expertise, that's a debatable subject .

H2O @ about 1 year ago

Spotsylvania Courthouse, VA 22553, USA

6c48fb73634fa41fe7915a7faf370ee7

now now Slappy condescension and cruelty are just manifestations of her impending breakdown and rebirth

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

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It's fine if you doubt me, h2o, just giving you fair warning. I wasn't asking for any recognition by you. Please: proceed to challenge me.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

6c48fb73634fa41fe7915a7faf370ee7

total meltdown

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

C767f03aeb282b9660d8157840047228

yeah I have anger issues, I admit.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

7feb020fb3d3aa6cf2752031cf61da89

I wasn't challenging anything. Reading problem? .

H2O @ about 1 year ago

Spotsylvania Courthouse, VA 22553, USA

6c48fb73634fa41fe7915a7faf370ee7

smart move

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

26e82c69bac3abe48cfce8aae262fda8

How much is crestor different than lipitor? Just curious

The Drew @ about 1 year ago

Yorkville, New York, NY

B35527b232c45def78db4f6949419182

Rosuvastatin is more potent, but the 40 mg dose gives you about the same LDL effects as the 80 mg atorvastatin dose. http://www.ncbi.nlm.nih.gov/pubmed/22085316

Tjaden Froyda @ about 1 year ago

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LDL reduction isn't the same as mortality benefit though. There are no direct h2h comparisons on actual CV, so the best we have is simulation modeling out of Robert Woods Johnson.

Tjaden Froyda @ about 1 year ago

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http://www.ncbi.nlm.nih.gov/pubmed/26664148 Rosuvastatin is slightly better.

Tjaden Froyda @ about 1 year ago

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Is there a patent still in force for a rosuvastatin/atorvastatin blend, or did that die along with the rosuvastatin patent? I think a blend is presently on the market, isn't it? I can find out if you don't know but it's a pain in the ass.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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I can't find out about the market stuff though, simple Google searching aside. Hoping you'll be able to help me out there, Mr. Ed.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

B35527b232c45def78db4f6949419182

I'm not aware of a rosuvastatin/atovastatin combo pill. Clinically that'd be pointless. You may be thinking of various statin combinations with Ezetimibe (Vytorin, Rosuzet, Liptruzet)

Tjaden Froyda @ about 1 year ago

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That said, wouldn't be surprised if the patent existed. My understanding is that these combinations are novel patents (new formulation) and could still be alive even if the single agent's exclusivity expired

Tjaden Froyda @ about 1 year ago

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Is there now precedence against this kinda sleazeball move by another company for another drug?

The Drew @ about 1 year ago

Yorkville, New York, NY

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Idk. Evil?

Tjaden Froyda @ about 1 year ago

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Yes, this slams the door shut on this specific tactic. They'll think of some other evil plot though, you can bet on it. It's worthwhile to throw lots of mud at that wall: if something sticks, it's worth more than every penny you've spent.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

Mr. Ed, there could be a patent on the combo that is completely separate from the original rosuvastatin patent, though it would be hard to get. You'd have to show some special effect of combining. Even then it would be tough.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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For example, one of the combinations I mentioned above https://www.techdirt.com/articles/20130510/10164723033/merck-evergreens-off-patent-lipitor-creating-combination-drug-with-no-additional-benefit.shtml

Tjaden Froyda @ about 1 year ago

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Drew - if you want more info on shady evergreening practices, Google "pharmaceutical lifecycle management"

Tjaden Froyda @ about 1 year ago

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Yeah this has become a major problem in the pharma marketplace. Another lovely practice is paying off the generics companies (there are several whose sole business is manufacturing generic drugs) to NOT enter the market at the time the patent is set

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

to expire. Effectively they will pay the thin profit margin expected by the generic manufacturer for a period of time, and in exchange they get a continued monopoly. Who benefits there? Not us!

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

This practice was only recently squashed. The people did not enjoy the benefits of public ownership at the end of the patent term, which is the bargain struck upon the foundation of the U.S.patent office.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

The generics guys, incredibly, successfully lobbied Congress to get initial periods of GENERIC exclusivity. The first generic producer of a drug gets a six month period of exclusivity.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

And the pharma industry successfully lobbied to get patent term extensions to cover the (admittedly long) period of regulatory approvals they must go through to get a drug on the market. While the patent term ticks away at 20 years from date of

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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filing, which usual happens before regulatory even gears up, the regulatory stuff can take 10 years or more before the drug sees the pharmacy shelf. So I do understand the need of the lobby. But they got that, and the don't deserve one bit more.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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The taxpayers help pay for their research too. Not all of it of course, but a chunk. Remember that next time they whine about all the money they spend on developing drug candidates.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

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For a blockbuster drug, they hire huge contingencies of patent litigators at $1000/hr or more to go to court for any possible legal angle they think could buy them even an extra day of patent protection. The op is one of those things.

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

C767f03aeb282b9660d8157840047228

(Well I should have said "exclusivity" not patent protection. I think it's inescapable even to them that their patent expired.)

Dr. Evil @ about 1 year ago

Lakeland, MN 55043, USA

6c48fb73634fa41fe7915a7faf370ee7

kind of like the way Obama came riding in on George Bush's coattails

Mr. Pink @ about 1 year ago

Strongsville, OH, USA

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